The serum concentration of infliximab obtained 1 hour after infusion approximates the C max for infliximab. At week 0, the median serum concentrations of the 1 hour–postinfusion samples were 68.6 μg/ml and 219.1 μg/ml for subjects receiving 3 mg/kg and 10 mg/kg infliximab, respectively, every 8 weeks (Table 1 ).

The infliximab concentration was significantly related with antibody levels before 1232 serum samples from 90 patients with CD and UC treated with infliximab, 

Methods A prospective cohort study was carried out in 104 IBD patients seen at a The Relationship Between Serum Infliximab and Adalimumab Concentrations and Their Corresponding Anti-Drug Antibody Levels: Analysis of over 50,000 Patient Results Using Lab Developed Chemiluminescent Immunoassays Kelly Y. Chun, Imir Metushi, Jeanne Eby, Steve Phagoo, Morgan Herle, James Iha & Jane M. Yang 1. o Serum infliximab (IFX) concentration: <1.0 ug/mL o Antibody to infliximab (ATI) concentration: <3.1 U/mL Facilities Description This test was developed and its performance characteristics determined by Prometheus Laboratories Inc. It has not been cleared or approved by the U.S. Food and Drug Administration. Infliximab concentrations tend to stabilize after 14 weeks (approximately 100 days). Quantitation of peak infliximab concentrations is strongly discouraged. The ATI assay has been verified to analyze infliximab and infliximab-dyyb (Inflectra, Pfizer Inc) with no analytical differences between the 2 drugs quantitation.

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serum infliximab concentrations at 16 weeks to those at baseline was 85% or less). Safety analyses were done in the safety population, which included participants who received at least one dose of CT-P13 and attended at least one 2018-06-01 · In our trial, serum concentrations of infliximab 16 weeks after switching to CT-P13 were non-inferior to those with originator infliximab in patients with stable disease on maintenance therapy. Likewise, no difference in immunogenicity, as measured by concentrations of anti-drug antibodies, was noted before and after switching. Serum concentrations were also obtained prior to dosing and one hour post-dosing. Infliximab levels were measured by ELISA (lowest detectable level = 0.1 μg/ml). 2017-03-31 · Serum infliximab (IFX) and antibody-to-infliximab (ATI) levels are objective parameters that may help in the therapeutic decisions during maintenance biological therapy.

Overall median CRP was 1.8 mg/L (IQR, 0.7–4.8 mg/L) and median infliximab TC was 4.6 μg/mL (IQR, 2.4–7.3 μg/mL). Of 275 patients, the infliximab TC was >7 μg/mL in 72 patients (26.2%); between 3 and 7 μg/mL in 121 patients (44.0%); detectable but <3 μg/mL in 58 patients (21.1%); and undetectable in 24 patients (8.7%).

PROMETHEUS® Anser® IFX measures both serum infliximab levels and antibodies to infliximab – valuable information to help guide your treatment decisions for patients who lose response to infliximab. 2020-07-15 · Abstract. Despite a robust exposure–response relationship of infliximab in inflammatory bowel disease (IBD), attempts to adjust dosing to individually predicted serum concentrations of infliximab (SICs) are lacking. Compared with labor‐intensive conventional software for pharmacokinetic (PK) modeling (eg, NONMEM) dashboards are easy‐to‐use programs Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis.

Serum concentrations were also obtained prior to dosing and one hour post-dosing. Infliximab levels were measured by ELISA (lowest detectable level = 0.1 μg/ml).

of 1, 3, 5, 10 or 20 mg/kg of infliximab yielded dose proportional increases in the maximum serum concentration (Cmax) and area under the concentration-time curve (AUC).

4, 5 However are (POC) devices for quantification of serum infliximab concentration with 2 validated ELISA assays in children with IBD. Methods: We studied 32 serum samples from 19 children with IBD treated with infliximab. Serum samples were collected immediately before drug infusion (trough level). Infliximab was measured using 2 POC infliximab assays, Quantum Blue (POC IFX/QB) and Rida Quick (POC IFX/RQ Whiskers boxplot (5th–95th centile) representing the C-reactive protein concentration (mg/L) in samples with an infliximab (IFX) trough concentration above or below the threshold of 3 μg/mL, both for antibody to IFX (ATI) negative (<3.13 U/mL) and ATI positive (≥3.13 U/mL) samples.
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Objective Although low infliximab trough concentrations and antibodies to infliximab (ATI) are associated with poor outcomes in patients with Crohn's disease (CD), the clinical relevance of ATI in patients with adequate infliximab concentrations is uncertain.

serum infliximab concentrations at 16 weeks to those at baseline was 85% or less). Safety analyses were done in the safety population, which included participants who received at least one dose of CT-P13 and attended at least one 2018-06-01 · In our trial, serum concentrations of infliximab 16 weeks after switching to CT-P13 were non-inferior to those with originator infliximab in patients with stable disease on maintenance therapy.
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At week 14 of treatment, patients were randomly assigned (1:1:1) to 3 infliximab maintenance groups: dose increases (2 maximum) in steps of 2.5 mg/kg based on clinical symptoms and biomarker analysis and/or serum infliximab concentrations (dose intensification strategy [DIS]1 group); dose increase from 5 to 10 mg/kg based on the same criteria (DIS2 group); dose increase to 10 mg/kg based on clinical symptoms alone (controls).

2014-12-01 · The serum infliximab concentration threshold of 5.1 μg/mL at week 14 is consistent with that defined by ROC analysis for week 30 (3.7 μg/mL) when consideration is given to the fact that the concentration at week 14 theoretically is expected to be slightly higher than the concentration at week 30 because only 8 weeks (1 maintenance dose interval) have elapsed before the week-14 sampling, after the 3 induction doses at weeks 0, 2, and 6. Serum samples were collected immediately before drug infusion (trough level). Infliximab was measured using 2 POC infliximab assays, Quantum Blue (POC IFX/QB) and Rida Quick (POC IFX/RQ), and 2 ELISA assays: Lisa-Tracker (used as primary reference), and Promonitor (used as second control). Serum infliximab levels were measured using an enzyme-linked immunosorbent assay.